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The Lead

Targeting Cancer with a Triple Threat

April 16, 2014 10:07 am | by Anne Trafton, MIT News Office | News | Comments

Delivering chemotherapy drugs in nanoparticle form could help reduce side effects by targeting the drugs directly to the tumors. Scientists have developed nanoparticles that deliver one or two chemotherapy drugs, but it has been difficult to design particles that can carry any more than that in a precise ratio. MIT chemists have devised a new way to build such nanoparticles, making it much easier to include three or more different drugs.

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Controlled Environments

Understanding the Implications of the Classification System

April 16, 2014 11:27 am | by Jeanne Moldenhauer | Articles | Comments

Over the past few years there has been an increasing trend to change from previous classification systems used to the ISO classification systems in ISO 14644-1. However, many companies have continued to use the traditional Class 100, 10,000, 100,000 room classification system from Federal Standard 209-e. In Europe, the GMPs utilize another system—Grades A through D.


Measuring Airflow in the Cleanroom

April 16, 2014 11:17 am | by Patrice Galvin and MaryBeth DiDonna | Articles | Comments

Velocity can affect particle deposition in either a positive or negative way.                                                     


The Building Commissioning Maze, Part 2

April 16, 2014 10:49 am | by Richard Bilodeau, PE | SMRT - Architects and Engineers | Articles | Comments

I’m now hearing a lot about “ongoing commissioning” and “continuous commissioning” of facilities. How can I ensure that the commissioning process will be well-organized and deliver the best results?                        


Selecting the Right Equipment For Your Cleanroom

April 15, 2014 3:18 pm | by Kathie Kalafatis | CleanAir Solutions, Inc. | Articles | Comments

There are many factors that must be considered before selecting equipment for your cleanroom or laboratory space.  Take the time to review the criteria with your co-workers and follow these five simple steps to ensure you order the right equipment for your next project.


Will Today’s Approach to Contamination Control Work Tomorrow?

April 15, 2014 2:58 pm | by Essentra Porous Technologies | Essentra Porous Technologies (formerly Lymtech Scientific) | Articles | Comments

It’s only natural that contamination control in today’s world of critical environments is in a constant state of evolution. After all, the complexities of facilities and processes flow from the increasing intricacies of end products. And throughout the continued development of environmental monitoring programs, it pays dividends to recognize that what works today may not be the best solution for the future.


Upholding Compliance through Proper Maintenance

April 15, 2014 2:32 pm | by Kristyn Henke | Hutchins & Hutchins, Inc., Cleanroom Division | Articles | Comments

There are many factors to consider for the proper maintenance of your cleanroom and its equipment and supplies. Before any cleaning is done, make sure you are using the correct cleaning equipment, supplies, procedures, and knowledgeable staff. Each class of cleanroom has its own specific cleaning equipment and solvents.


Routine Maintenance of Critical Cleaning Equipment

April 15, 2014 2:00 pm | Videos | Comments

Welcome to the Controlled Environments' audio series of cleanroom tips. In this tip, "Routine Maintenance of Critical Cleaning Equipment," it should go without saying that routine maintenance of equipment is essential. Developing a defined equipment maintenance audit can avoid process catastrophes.


Medical Device Manufacturing Shifts to Lifecycle

April 15, 2014 11:33 am | by Barbara Kanegsberg and Ed Kanegsberg | BFK Solutions, LLC | Articles | Comments

Increasing design complexities pose challenges for cleaning processes.                                                


FDA Tackles Broken Generic Drug Application Process

April 15, 2014 11:17 am | by Bikash Chatterjee | Articles | Comments

The spirit of this guidance is to speed access to generic medicines.                                                         


Nano Shake-Up

April 15, 2014 10:02 am | by Diane Kukich | News | Comments

Significant advances have been made in chemotherapy over the past decade, but targeting drugs to cancer cells while avoiding healthy tissues continues to be a major challenge. Nanotechnology has unlocked new pathways for targeted drug delivery, including the use of nanocarriers, or capsules, that can transport cargoes of small-molecule therapeutics to specific locations in the body.


Semiconductor Company Announces Investment

April 15, 2014 9:20 am | News | Comments

NXP Semiconductors N.V. has announced its investment in Senseg, which offers next-generation spatial haptic feedback technology. The investment is part of NXP’s drive to lead in new user interface technologies for mobile, consumer, and automotive applications. Existing investors in Senseg also participated in this Series B round.


Controlling Electrostatic Discharge in Cleanroom Packaging

April 14, 2014 4:40 pm | by Michael Mills, Kathy Mills, Justin Mills, Laura Clark | Articles | Comments

What you need to know when packaging ESD-sensitive items.                                                        


Cleanroom Garment Selection

April 14, 2014 3:19 pm | by Jan Eudy | Articles | Comments

A primer on reusable and disposable cleanroom garments as well as garment testing and laundering.                                          


Interphex 2014 Wrap-Up

April 14, 2014 2:49 pm | Controlled Environments Magazine | Articles | Comments

Shows such as Interphex give us the chance to learn about what’s new in the industry, such as updated standards, current trends, and exciting new products. Meeting with our reader base in person also gives us the opportunity to discuss what they like about Controlled Environments and what they wish we’d cover more often.


Tunable Semiconductors Will Allow Better Solar Cells

April 14, 2014 12:04 pm | News | Comments

One of the great problems in physics is the detection of electromagnetic radiation – that is, light – which lies outside the small range of wavelengths that the human eye can see. Now, researchers have discovered a way to use existing semiconductors to detect a far wider range of light than is now possible, well into the infrared range.



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